A Bayesian cure rate model with dispersion induced by discrete frailty

Bayesian cure rate frailty models with application to a root canal therapy study.

Due to natural or artificial clustering, multivariate survival data often arise in biomedical studies, for example, a dental study involving multiple teeth from each subject. A certain proportion of subjects in the population who are not expected to experience the event of interest are considered to be "cured" or insusceptible. To model correlated or clustered failure time data incorporating a ...

A General Transformation Class of Semiparametric Cure Rate Frailty Models

We consider a class of cure rate frailty models for multivariate failure time data with a survival fraction. This class is formulated through a transformation on the unknown population survival function. It incorporates random effects to account for the underlying correlation, and includes the mixture cure model and the proportional hazards cure model as two special cases. We develop efficient ...

Bayesian cure rate model accommodating multiplicative and additive covariates

We propose a class of Bayesian cure rate models by incorporating a baseline density function as well as multiplicative and additive covariate structures. Our model naturally accommodates zero and non-zero cure rates, which provides an objective way to examine the existence of a survival fraction in the failure time data. An inherent parameter constraint needs to be incorporated into the model f...

Frailty models with a cure fraction for modeling clustered discrete survival data

On Share Frailty Cure Model: An Application On Cervical Cancer

Survival analyses are greatly used in medical research especially frailty models which are mostly used to account for heterogeneity in time-to-event. Over the years treatment of cancer has progressed with some patients being cured from different type of cancer. Survival analysis is more focused on subjects that are less at risk of recurrences, metastasis or death after the first treatment as th...